![]() Adrenal hypertrophy/adrenocortical cellular hypertrophy are common findings in toxicity studies and also often incorrectly attributed to ‘stress’: these findings should not be attributed to stress unless there is clear evidence that the adrenal cortex is also functional. The adrenal is a vital organ and dysfunction of the steroidogenic pathways for either glucocorticoid or mineralocorticoid production can result in significant morbidity and mortality. ![]() The adrenal gland is the most common toxicological target in the endocrine system and reasons for this vulnerability have been discussed. Harvey, in Comprehensive Toxicology, 2010 11.13.7 Conclusions
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